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2006 |
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| Publication | Author Affiliation | Website
| PDF | | Harrison BC, Mi-Sung Kim, Eva van Rooij, Craig F. Plato, Philip J. Papst, Rick B. Vega, John A. McAnally, James A. Richardson, Rhonda Bassel-Duby, Eric N. Olson, and Timothy A. McKinsey. (2006) Regulation of Cardiac Stress Signaling by Protein Kinase D1. Mol. Cell. Biol., May 2006; 26: 3875 - 3888. | Myogen | Link | | | Vidali L, Feng Chen, Gregor Cicchetti, Yasutaka Ohta, and David J. Kwiatkowski. (2006) Rac1-null Mouse Embryonic Fibroblasts Are Motile and Respond to Platelet-derived Growth Factor. Mol. Biol. Cell, May 2006; 17: 2377 - 2390. | Brigham and Women's Hospital and Harvard Medical School | Link | | |
| Lamian V, Rich A, Ma Z, Li J, Seethala R, Gordon D, and Dubaquie Y. (2006) Characterization of Agonist-Induced Motilin Receptor Trafficking and Its Implications for Tachyphylaxis. Mol. Pharmacol., 69: 109 - 118. | Bristol Myers Squibb | Link | | | Davey RE, Zandstra PW. (2006) Spatial organization of embryonic stem cell responsiveness to autocrine gp130 ligands reveals an autoregulatory stem cell niche. Stem Cells. Nov;24(11):2538-48. | Institute of Biomaterials and Biomedical Engineering, University of Toronto | Link | | | Yan P, Nanamori M, Sun M, Zhou C, Cheng N, Li N, Zheng W, Xiao L, Xie X, Ye RD, and Wang MW. (2006) The Immunosuppressant Cyclosporin A Antagonizes Human Formyl Peptide Receptor through Inhibition of Cognate Ligand Binding. J. Immunol., 177: 7050 - 7058. | National Center for Drug Screening, China | Link | | | Culbert AA, Skaper SD, Howlett DR, Evans NA, Facci L, Soden PE, Seymour ZE, Guillot F, Gaestel M, and Richardson JC. (2006) MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease. J. Biol. Chem., 281: 23658 - 23667. | GlaxoSmithKline Research and Development Limited | Link | | | Qian MD, Jie Zhang, Xiang-Yang Tan, Andrew Wood, Davinder Gill, and Seongeun Cho. (2006) Novel Agonist Monoclonal Antibodies Activate TrkB Receptors and Demonstrate Potent Neurotrophic Activities. J. Neurosci., Sep 2006; 26: 9394 - 9403. | Wyeth Research | Link | | | Fryknäs M, Rickardson L, Wickström M, Dhar S, Lövborg H, Gullbo J, Nygren P, Gustafsson MG, Isaksson A, Larsson R. (2006) Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model. J Biomol Screen. Aug;11(5):457-68 . | Department of Genetics and Pathology, Uppsala University | Link | | | Park HJ, Partridge E, Cheung P, Pawling J, Donovan R, Wrana JL, Dennis JW. (2006) Chemical enhancers of cytokine signaling that suppress microfilament turnover and tumor cell growth. Cancer Res. Apr 1;66(7):3558-66. | University of Toronto | Link | | | Trask OJ Jr, Baker A, Williams RG, Nickischer D, Kandasamy R, Laethem C, Johnston PA, Johnston PA. (2006) Assay development and case history of a 32K-biased library high-content MK2-EGFP translocation screen to identify p38 mitogen-activated protein kinase inhibitors on the ArrayScan 3.1 imaging platform. Methods Enzymol;414:419-39. | Eli Lilly and Company | Link | | | Nickischer D, Laethem C, Trask OJ Jr, Williams RG, Kandasamy R, Johnston PA, Johnston PA. (2006) Development and implementation of three mitogen-activated protein kinase (MAPK) signaling pathway imaging assays to provide MAPK module selectivity profiling for kinase inhibitors: MK2-EGFP translocation, c-Jun, and ERK activation. Methods Enzymol;414:389-418. | Eli Lilly and Company | Link | | | Williams RG, Kandasamy R, Nickischer D, Trask OJ Jr, Laethem C, Johnston PA, Johnston PA. (2006) Generation and characterization of a stable MK2-EGFP cell line and subsequent development of a high-content imaging assay on the Cellomics ArrayScan platform to screen for p38 mitogen-activated protein kinase inhibitors. Methods Enzymol. ;414:364-89. | Eli Lilly and Company | Link | | | Borchert KM, Sells Galvin RJ, Hale LV, Trask OJ, Nickischer DR, Houck KA. (2006) Screening for activators of the wingless type/Frizzled pathway by automated fluorescent microscopy.Methods Enzymol. ;414:140-50. | Eli Lilly and Company | Link | | | Lundholt BK, Heydorn A, Bjørn SP, Praestegaard M. (2006) A simple cell-based HTS assay system to screen for inhibitors of p53-Hdm2 protein-protein interactions. Assay Drug Dev Technol. Dec;4(6):679-88. | BioImage | Link | | | Grånäs C, Lundholt BK, Loechel F, Pedersen HC, Bjørn SP, Linde V, Krogh-Jensen C, Nielsen EM, Praestegaard M, Nielsen SJ. (2006) Identification of RAS-mitogen-activated protein kinase signaling pathway modulators in an ERF1 redistribution screen. J Biomol Screen. Jun;11(4):423-34. | BioImage | Link | | | Richards GR, Smith AJ, Parry F, Platts A, Chan GK, Leveridge M, Kerby JE, Simpson PB. (2006) A morphology- and kinetics-based cascade for human neural cell high content screening. Assay Drug Dev Technol. Apr;4(2):143-52 | The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK. | Link | | | Zhang T, Stilwell JL, Gerion D, Ding L, Elboudwarej O, Cooke PA, Gray JW, Alivisatos AP, Chen FF (2006) Cellular effect of high doses of silica-coated quantum dot profiled with high throughput gene expression analysis and high content cellomics measurements. Nano Lett. Apr;6(4):800-8. | Lawrence Berkeley National Laboratory | Link | | | Fowler A, Seifert N, Acker V, Woehrle T, Kilpert C, de Saizieu A. (2006) A Nonradioactive High-Throughput / High-Content Assay for Measurement of the Human Serotonin Reuptake Transporter Function In Vitro. J Biomol Screen. Nov 12 | DSM Nutritional Products | Link | | | Richards GR, Smith AJ, Cuddon P, Ma QP, Leveridge M, Kerby J, Roderick HL, Bootman MD, Simpson PB. (2006) The JAK3 inhibitor WHI-P154 prevents PDGF-evoked process outgrowth in human neural precursor cells. J Neurochem. Apr;97(1):201-10. | Merck and Co | Link | | | Hassan SB, Lovborg H, Lindhagen E, Karlsson MO, Larsson R. (2006) CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. Anticancer Res. Nov-Dec;26(6B):4431-6 | University Hospital, Uppsala, Sweden | Link | | | William J. Buchser, Jose R. Pardinas, Yan Shi, John L. Bixby, and Vance P. Lemmon. (2006) 96-Well electroporation method for transfection of mammalian central neurons. BioTechniques® November Volume 41, Number 5: pp 619-624 | University of Miami | Link | | | Grove LE, Ghosh RN. (2006) Quantitative characterization of mitosis-blocked tetraploid cells using high content analysis. Assay Drug Dev Technol. Aug;4(4):421-42 | Cellomics Inc. | | | | Soncini C, Carpinelli P, Gianellini L, Fancelli D, Vianello P, Rusconi L, Storici P, Zugnoni P, Pesenti E, Croci V, Ceruti R, Giorgini ML, Cappella P, Ballinari D, Sola F, Varasi M, Bravo R, Moll J. (2006) PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity. Clin Cancer Res. Jul 1;12(13):4080-9. | Nerviano Medical Sciences | | | | Willmarth NE, Ethier SP. (2006) Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells. J Biol Chem. Oct 10 | University of Michigan and Wayne State University School of Medicine | | | | Ross S, Chen T, Yu V, Tudor Y, Zhang D, Liu L, Tamayo N, Dominguez C, Powers D. (2006) High-Content Screening Analysis of the p38 Pathway: Profiling of Structurally Related p38alpha Kinase Inhibitors Using Cell-Based Assays. Assay Drug Dev Technol. Aug;4(4):397-409 | Amgen | | | | Bokhari SM, Zhou L, Karasek MA, Paturi SG, Chaudhuri V. (2006) Regulation of skin microvasculature angiogenesis, cell migration, and permeability by a specific inhibitor of PKCalpha. J Invest Dermatol. Feb;126(2):460-7 | Stanford University School of Medicine | | | Wipf P, Graham TH, Vogt A, Sikorski RP, Ducruet AP, Lazo JS (2006) Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product. Chem Biol Drug Des 67(1):66-73
| University of Pittsburgh | | | | Gasparri F, Cappella P, Galvani A. (2006) Multiparametric Cell Cycle Analysis by Automated Microscopy. J Biomol Screen. Sep;11(6):586-98 | Nerviano Medical Sciences | | | | O'Brien PJ, Irwin W, Diaz D, Howard-Cofield E, Krejsa CM, Slaughter MR, Gao B, Kaludercic N, Angeline A, Bernardi P, Brain P, Hougham C. (2006) High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening. Arch Toxicol. Apr 6 DOI: 10.1007/s00204-006-0091-3 | Pfizer | | | | Inglefield JR, Larson CJ, Gibson SJ, Lebrec H, Miller RL. (2006) Apoptotic Responses in Squamous Carcinoma and Epithelial Cells to Small-Molecule Toll-like Receptor Agonists Evaluated with Automated Cytometry. J Biomol Screen. Sep;11(6):575-85 | 3M Pharmaceuticals | | | Wheeler RT, Fink GR. (2006) A drug-sensitive genetic network masks fungi from the immune system. PLoS Pathog. Apr;2(4):e35.
| Whitehead Institute for Biomedical Research | | | | Amy Barabasz, Briana Foley, James C. Otto, Anisa Scott, John Rice. (2006) The Use of High-Content Screening for the Discovery and Characterization of Compounds That Modulate Mitotic Index and Cell Cycle Progression by Differing Mechanisms of Action. ASSAY and Drug Development Technologies. Apr 2;Vol. 4, No. 2: 153-163 | Serenex | | | McIlvain HB, Baudy A, Sullivan K, Liu D, Pong K, Fennell M, Dunlop J. (2006) Pituitary adenylate cyclase-activating peptide (PACAP) induces differentiation in the neuronal F11 cell line through a PKA-dependent pathway. Brain Res. 1077(1):16-23.
| Wyeth | | | | Fennell M, Chan H, Wood A. (2006) Multiparameter measurement of caspase 3 activation and apoptotic cell death in NT2 neuronal precursor cells using high-content analysis. J Biomol Screen. Apr;11(3):296-302. | Wyeth | | | | Morelli JK, Buehrle M, Pognan F, Barone LR, Fieles W, Ciaccio PJ. (2006) Validation of an in vitro screen for phospholipidosis using a high-content biology platform. Cell Biol Toxicol. Jan;22(1):15-27. | AstraZeneca | | | | Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE. (2006). A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 2006 Mar24: 1283-1298. | MIT | | | | Morelli JK, M Buehrle, F Pognan, LR Barone, W Fieles, PJ Ciaccio (2006). Validation of an in vitro screen for phospholipidosis using a high-content biology platform. Cell Biol Toxicol. 2006 Jan;22(1):15-27 | Safety Assessment, US | |  | | Volkov Y, A Long, M Freeley, L Golden-Mason, C O'Farrelly, A Murphy, D Kelleher (2006). The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration. Gastroenterology. 2006 Feb;130(2):482-92 | Trinity College | | | | Tao R, L Wang, CH Chen, SH Wang, RA Demarco, MT Lotze, NL Thai, JJ Fung, L Lu, S Qian (2006). Mechanistic insights into achievement of cardiac allograft long-term survival by treatment with immature dendritic cells and sub-dose sirolimus. J Heart Lung Transplant. 2006 Mar;25(3):310-9 | University of Pittsburgh | | | | Björklund M, M Taipale, M Varjosalo, J Saharinen, J Lahdenperä and J Taipale (2006) Identification of pathways regulating cell size and cell-cycle progression by RNAi. Nature 439:1009-1013 | Biomedicum Helsinki | | | | Lovborg H, F Oberg, L Rickardson, J Gullbo, P Nygren, R Larsson (2006) Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram. Int J Cancer 118(6): 1577-80 | Uppsala University | | |
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