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2007 |
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| Publication | Author Affiliation | Website
| PDF | | Benanti JA, Cheung SK, Brady MC, Toczyski DP.(2008). A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch.Nat Cell Biol. 2007 Oct;9(10):1184-91. | Department of Biochemistry and Biophysics, Cancer Research Institute, University of California, San Francisco | Link | | | Huang X, Li M, Xu B, Zhu X, Deng Z, Lin W. (2007) Proteasome and NF-kappaB inhibiting phaeophytins from the green alga Cladophora fascicularis. Molecules. Mar 21;12(3):582-92. | State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China. | Link | | | Tao CY, Hoyt J, Feng Y. (2007) A support vector machine classifier for recognizing mitotic subphases using high-content screening data. J Biomol Screen. Jun;12(4):490-6. | Genome and Proteome Sciences Novartis Institutes for Biomedical Research | Link | | | Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, Zhu H, Yu AD, Xie X, Ma D, Yuan J. (2007) Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A. Nov 27;104(48) | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China | Link | | | Dürr O, Duval F, Nichols A, Lang P, Brodte A, Heyse S, Besson D. (2007) Robust hit identification by quality assurance and multivariate data analysis of a high-content, cell-based assay. J Biomol Screen. Dec;12(8):1042-9. | Genedata AG | Link | | | Plun-Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, Frith D, Harvey K, Deas E, Harvey RJ, McDonald N, Wood NW, Martins LM, Downward J. (2007) The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol. Nov;9(11):1227-9. | Signal Transduction, Cancer Research UK London Research Institute | Link | | | D. Kent Arrell, Nicolas J. Niederländer, Randolph S. Faustino, Atta Behfar, Andre Terzic (2007) Cardioinductive Network Guiding Stem Cell Differentiation Revealed by Proteomic Cartography of Tumor Necrosis Factor -Primed Endodermal Secretome. Stem Cells Vol. 26 No. 2 February, pp. 387 -400 | Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Mayo Clinic College of Medicine | Link | | To K, Y. Zhao, H. Jiang, K. Hu, M. Wang, J. Wu, C. Lee, D. W. Yokom, A. L. Stratford, U. Klinge, P. R. Mertens, C. S. Chen, M. Bally, D. Yapp, and S. E. Dunn. (2007) The Phosphoinositide-Dependent Kinase-1 Inhibitor 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-acetamide (OSU-03012) Prevents Y-Box Binding Protein-1 from Inducing Epidermal Growth Factor Receptor. Mol. Pharmacol. 72: 641 - 652.
| University of British Columbia, RWTH Aachen University, Aachen, Germany and Ohio State University | Link | | | Baniecki ML, Wirth DF, and Clardy J. (2007) High-Throughput Plasmodium falciparum Growth Assay for Malaria Drug Discovery. Antimicrob. Agents Chemother.; 51: 716 - 723. | Harvard Medical School | Link | | Gupta V,Gylling A, Alonso JL, Sugimori T, Ianakiev P, Xiong JP, and Arnaout MA. (2007) The ß-tail domain (ßTD) regulates physiologic ligand binding to integrin CD11b/CD18. Blood, 109: 3513 - 3520.
| Harvard Medical School | Link | | | Wickström M, Johnsen JI, Ponthan F, Segerström L, Sveinbjörnsson B, Lindskog M, Lövborg H, Viktorsson K, Lewensohn R, Kogner P, Larsson R, and Gullbo J. (2007) The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo. Mol. Cancer Ther., 6: 2409 - 2417. | Uppsala University Hospital | Link | | | Doi H, Okamura K, Bauer PO, Furukawa Y, Shimizu H, Kurosawa M, Machida Y, Miyazaki H, Mitsui K, Kuroiwa Y, and Nukina N. (2007) RNA-binding protein TLS is a major nuclear aggregate-interacting protein in Huntingtin exon 1 with expanded polyglutamine-expressing cells. J. Biol. Chem., 10.1074/jbc.M705306200. | RIKEN Brain Science Institute | Link | | | Raccor BS, Vogt A, Sikorski RP, Madiraju C, Balachandran R, Montgomery K, Shin Y, Fukui Y, Jung WH, Curran DP, and Day BW. (2007) Cell-Based and Biochemical Structure-Activity Analyses of Analogues of the Microtubule Stabilizer Dictyostatin. Mol. Pharmacol., 10.1124/mol.107.042598 | University of Pittsburgh
| Link | | | Guan Y, Kuo WL, Stilwell JL, Takano H, Lapuk AV, Fridlyand J, Mao JH, Yu M, Miller MA, Santos JL, Kalloger SE, Carlson JW, Ginzinger DG, Celniker SE, Mills GB, Huntsman DG, and Gray W. (2007) Amplification of PVT1 Contributes to the Pathophysiology of Ovarian and Breast Cancer. Clin. Cancer Res., 13: 5745 - 5755. | Lawrence Berkeley National Laboratory | Link | | | Steinberg BE, Scott CC, and Grinstein S. (2007) High-throughput assays of phagocytosis, phagosome maturation, and bacterial invasion. Am J Physiol Cell Physiol, 292: C945 - C952. | The Hospital for Sick Children, Toronto | Link | | | Joslin EJ, Opresko LK, Wells A, H. Wiley HS, and Lauffenburger DA. (2007) EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation. J. Cell Sci., 120: 3688 - 3699. | Department of Biological Engineering, MIT | Link | | | Badura L, Swanson T, Adamowicz W, Adams J, Cianfrogna J, Fisher K, Holland J, Kleiman R, Nelson F, Reynolds L, St. Germain K, Schaeffer E, Tate B, and Sprouse J. (2007) An Inhibitor of Casein Kinase I Induces Phase Delays in Circadian Rhythms under Free-Running and Entrained Conditions. J. Pharmacol. Exp. Ther., Aug 2007; 322: 730 - 738. | Pfizer Global Research and Development | Link | | | Tian F, Grimaldo S, Fugita M, Cutts J, Vujanovic NL, and Li LY. (2007) The Endothelial Cell-Produced Antiangiogenic Cytokine Vascular Endothelial Growth Inhibitor Induces Dendritic Cell Maturation. J. Immunol., 179: 3742 - 3751. | University of Pittsburgh Cancer Institute and Department of Pathology | Link | | | Howes AL, Chiang GG, Lang ES, Ho CB, Powis G, Vuori K, and Abraham RT. (2007) The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures. Mol. Cancer Ther., 6: 2505 - 2514. | Burnham Institute for Medical Research | Link | | | Rigamonti D, Bolognini D, Mutti C, Zuccato C, Tartari M, Sola F, Valenza M, Kazantsev AG, and Cattaneo E. (2007) Loss of Huntingtin Function Complemented by Small Molecules Acting as Repressor Element 1/Neuron Restrictive Silencer Element Silencer Modulators. J. Biol. Chem., Aug 2007; 282: 24554 - 24562. | University of Milan | Link | | | Gonzalez-Suarez E, Branstetter D, Armstrong A, Dinh H, Blumberg H, and Dougall WC. (2007) RANK Overexpression in Transgenic Mice with Mouse Mammary Tumor Virus Promoter-Controlled RANK Increases Proliferation and Impairs Alveolar Differentiation in the Mammary Epithelia and Disrupts Lumen Formation in Cultured Epithelial Acini. Mol. Cell. Biol., 27: 1442 - 1454. | Amgen | Link | | | Bednarek R, Boncela J, Smolarczyk K, Cierniewska-Cieslak A, Wyroba E, and Cierniewski CS. (2007) KU80 as a novel receptor for thymosin B4 that mediates its intracellular activity different from G-actin sequestering. J. Biol. Chem., Vol. 283, Issue 3, 1534-1544, | Medical University in Lodz, Poland | Link | | Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y. (2007) Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol. Nat Chem Biol. Jan;4(1):59-68.
| Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Department of Systems Biology, Harvard Medical School | Link | | | Arrell DK, Niederländer NJ, Faustino RS, Behfar A, Terzic A. (2007) Cardioinductive network guiding stem cell differentiation revealed by proteomic cartography of TNF{alpha}-primed enodermal secretome. Stem Cells. Nov 15 | Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology & Experimental Therapeutics, and Medical Genetics, Mayo Clinic College of Medicine, Rochester, Minnesota | Link | | | Tay YM, Tam WL, Ang YS, Gaughwin PM, Yang HH, Wang W, Liu R, George J, Ng HH, Perera RJ, Lufkin T, Rigoutsos I, Thomson AM, Lim B. (2007) MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells where it Causes Post-transcriptional Attenuation of Nanog and LRH1. Stem Cells. Oct 18 | Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore. | Link | | Lawrence JM, Singhal S, Bhatia B, Keegan DJ, Reh TA, Luthert PJ, Khaw PT, Limb GA. (2007) MIO-M1 cells and similar muller glial cell lines derived from adult human retina exhibit neural stem cell characteristics. Stem Cells. Aug;25(8):2033-43.
| Ocular Repair and Regeneration Biology Unit, Department of Cell Biology, Institute of Ophthalmology, London, UK. | Link | | | Peerani R, Rao BM, Bauwens C, Yin T, Wood GA, Nagy A, Kumacheva E, Zandstra PW. (2007) Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J. Nov 14;26(22):4744-55. | Institute of Biomaterials and Biomedical Engineering, University of Toronto | Link | | | Nabiev I, Mitchell S, Davies A, Williams Y, Kelleher D, Moore R, Gun'ko YK, Byrne S, Rakovich YP, Donegan JF, Sukhanova A, Conroy J, Cottell D, Gaponik N, Rogach A, Volkov Y. (2007) Nonfunctionalized Nanocrystals Can Exploit a Cell's Active Transport Machinery Delivering Them to Specific Nuclear and Cytoplasmic Compartments. Nano Lett. Nov 14;7(11):3452-3461 | Trinity College Dublin, University College Dublin, Technische Universität Dresden, Ludwig-Maximilians-Universität München | Link | | Gasparri F, Ciavolella A, Galvani A.
(2007) Cell-cycle inhibitor profiling by high-content analysis. Adv Exp Med Biol; 604:137-48. | Nerviano Medical Sciences, Milano, Italy. | Link | | | Sartore-Bianchi A, Gasparri F, Galvani A, Nici L, Darnowski JW, Barbone D, Fennell DA, Gaudino G, Porta C, Mutti L. (2007) Bortezomib inhibits nuclear factor-kappaB dependent survival and has potent in vivo activity in mesothelioma. Clin Cancer Res. Oct 1;13(19):5942-51. | Nerviano Medical Sciences, Milano, Italy. | Link
| | Michele Agler*, Margaret Prack, Yingjie Zhu, Janet Kolb, Kimberly Nowak, Rolf Ryseck, Ding Shen, Mary Ellen Cvijic, John Somerville, Steve Nadler, and Taosheng Chen (2007) A High-Content Glucocorticoid Receptor Translocation Assay for Compound Mechanism-of-Action Evaluation. J Biomol Screen. Dec;12(8):1029-41.
| Bristol Myers Squibb | Link | | | Wang J, Xie X. (2007) Development of a quantitative, cell-based, high-content screening assay for epidermal growth factor receptor modulators. Acta Pharmacol Sin. Oct;28(10):1698-704. | The National Center for Drug Screening, Shanghai Institute of Materia Medica | Link | | | Emily Walker, Minako Ohishi, Ryan E. Davey, Wen Zhang, Paul A. Cassar, Tetsuya S. Tanaka, Sandy D. Der, Quaid Morris, Timothy R. Hughes, Peter W. Zandstra, and William L. Stanford. (2007) Prediction and Testing of Novel Transcriptional Networks Regulating Embryonic Stem Cell Self-Renewal and Commitment. Cell Stem Cell, Vol 1, 71-86, 07 June. | University of Toronto | Link | | | Davey RE, Onishi K, Mahdavi A, Zandstra PW. (2007) LIF-mediated control of embryonic stem cell self-renewal emerges due to an autoregulatory loop. FASEB J. Jul;21(9):2020-32. | Univerity of Toronto | Link | | | Low J, Huang S, Dowless M, Blosser W, Vincent T, Davis S, Hodson J, Koller E, Marcusson E, Blanchard K, Stancato L. (2007) High-Content Imaging Analysis of the Knockdown Effects of Validated siRNAs and Antisense Oligonucleotides. J Biomol Screen. May 21. . | Eli Lilly and Company | Link | | | Mahdavi A, Davey RE, Bhola P, Yin T, Zandstra PW. (2007) Sensitivity Analysis of Intracellular Signaling Pathway Kinetics Predicts Targets for Stem Cell Fate Control. PLoS Comput Biol. Jul 6;3(7):e130 . | University of Toronto and The University of Japan | Link | | | Vogt A, Lazo JS. (2007) Discovery of protein kinase phosphatase inhibitors. Methods Mol Biol.;356:389-400. | University of Pittsburgh | Link | | | Vogt A, Lazo JS. (2007) Implementation of high-content assay for inhibitors of mitogen-activated protein kinase phosphatases. Methods. Jul;42(3):268-77. | University of Pittsburgh | Link | | | Wang Z, McPherson PA, Raccor BS, Balachandran R, Zhu G, Day BW, Vogt A, Wipf P. (2007) Structure-activity and High-content Imaging Analyses of Novel Tubulysins. Chem Biol Drug Des. Aug;70(2):75-86. | University of Pittsburgh | Link | | | Kerrison JB, Zack DJ. (2007) Neurite outgrowth in retinal ganglion cell culture. Methods Mol Biol;356:427-34 | Wilmer Eye Institute, Johns Hopkins Hospital | Link | | | O'Brien P, Haskins JR. (2007) In vitro cytotoxicity assessment. Methods Mol Biol.;356:415-25. | Safety Sciences Europe, Pfizer Globral Research and Development | Link | | | Buckbinder L, Crawford DT, Qi H, Ke HZ, Olson LM, Long KR, Bonnette PC, Baumann AP, Hambor JE, Grasser WA, Pan LC, Owen TA, Luzzio MJ, Hulford CA, Gebhard DF, Paralkar VM, Simmons HA, Kath JC, Roberts WG, Smock SL, Guzman-Perez A, Brown TA, Li M. (2007) Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc Natl Acad Sci U S A. Jun 19;104(25):10619-24. | Pfizer Global Reseach and Development | Link | | | Liu D, McIlvain HB, Fennell M, Dunlop J, Wood A, Zaleska MM, Graziani EI, Pong K. (2007) Screening of immunophilin ligands by quantitative analysis of neurofilament expression and neurite outgrowth in cultured neurons and cells. J Neurosci Methods. Apr 5. | Neuroscience Discovery Research, Wyeth Research | Link | | | Taylor DL. (2007) Past, present, and future of high content screening and the field of cellomics. Methods Mol Biol.;356:3-18. | Cellumen, Inc. | Link | | | Dawes LJ, Angell H, Sleeman M, Reddan JR, Wormstone IM. (2007) TGFbeta isoform dependent Smad2/3 kinetics in human lens epithelial cells: a Cellomics analysis. Exp Eye Res. May;84(5):1009-12. | Cambridge Antibody Technology | Link | | | Stilwell JL, Guan Y, Neve RM, Gray JW. (2007) Systems biology in cancer research: genomics to cellomics. Methods Mol Biol. 356:353-65. | Lawrence Berkeley National Laboratory | Link | | | Diaz D, Scott A, Carmichael P, Shi W, Costales C. (2007) Evaluation of an automated in vitro micronucleus assay in CHO-K1 cells. Mutat Res. Feb 28. | Cerep, Inc. | Link | | | Park JY, Arnaout MA, Gupta V. (2007) A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18. J Biomol Screen. Apr;12(3):406-17. | Harvard Medical School | Link | | | Rickardson L, Wickström M, Larsson R, Lövborg H. (2007) Image-Based Screening for the Identification of Novel Proteasome Inhibitors.J Biomol Screen. Mar;12(2):203-10 | Clinical Pharmacology University Hospital 581 85 Linköping Sweden | Link | | | Wickstrom M, Danielsson K, Rickardson L, Gullbo J, Nygren P, Isaksson A, Larsson R, Lovborg H. (2007) Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients. Biochem Pharmacol. Jan 1;73(1):25-33. | University Hospital, Uppsala, Sweden | Link | | | Van Sant C, Wang G, Anderson MG, Trask OJ, Lesniewski R, Semizarov D. Endothelin signaling in osteoblasts: global genome view and implication of the calcineurin/NFAT pathway.Mol Cancer Ther. 2007 Jan;6(1):253-61. | Abbott Laboratories | Link | | Back to top
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