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HCS Reagent Kits for Cell Morphology and Phenotypic Changes |
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DescriptionCellomics High-Content Screening (HCS) Reagents Kits are powerful tools for cell-based screening and analysis of specific molecular targets and biological parameters. Among the available kits are the designed to image and measure key cell morphological and phenotypic states. Cellomics HCS Reagent Kits are designed and validated with the Cellomics ArrayScan HCS Reader and BioApplication Software, together providing a “Total Solution” for high-content screening. HCS Reagent Kits are also fully compatible with other fluorescence-based HCS platforms and conventional fluorescence microscopy. HCS Reagent Kit Highlights- Available in validated single- and multiplexed configurations
- Robust – Z' factor > 0.3 for both multiplexed and single-target kits
- Complete sets of critical reagents and optimized protocols included to ensure reproducible results
- Superior probes developed using DyLight Fluorescent Labeling Reagents
- Validated with Cellomics ArrayScan Instruments and BioApplication Software
- Compatible with any fluorescence HCS/HCA platform and standard fluorescence microscopy
- Customized components and bulk quantities available
- See index page for all categories of Cellomics HCS Reagent Kits
About Cell Morphology and PhenotypeMaintaining and controlling cell shape, cell movement, cytokinesis and the organization of organelles is one of the most basic functions of the cell. Because change in these features is often the consequence of cellular differentiation, cellular toxicity, pathology or other critical cellular event or signaling, their measurement against potential therapeutic targets can be critical. The cytoskeleton is typically composed of microfilaments, microtubules, and intermediate filaments in the cell and plays a key role in the morphological change of cells. The cytoskeleton also facilitates proper function of other cellular proteins through direct binding, transporting, repositioning and sequestering these proteins. For certain cell types such as neurons, this morphological change of the cell is indispensable to gain the proper function in the tissue. Fluorescence microscopy and imaging, the basis of High Content Screening (HCS) provides both intensity as well as spatial information of the fluorescently-labeled constituents that are imaged and quantitatively analyzed. Spatial information, such as cell shape and morphology, sizes and arrangements of intracellular constituents, and the arrangement and location of cells relative to each other, can all be obtained from fluorescence microscopy and HCS. Other cell-based fluorescence assay methods such as flow cytometry, FLIPR, and homogeneous fluorescence signals in plate readers cannot provide this type of high-content data. Available Kits for Morphology and Phenotypic ChangesWe offer an extensive (and growing) line of optimized protocols and reagent kits for single- and multiplexed high-content analysis (HCA) of morphological, structural and phenotypic changes of whole cells and intracellular constituents. {Back to parent index page for all Cellomics HCS Reagent Kits}
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Last Updated ( Friday, 27 July 2007 )
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