Thinking of High Content Biology?
Introducing a low cost integrated solution for High Content Screening (HCS)

The Certified Thermo Scientific Cellomics ArrayScan Platform for High Content Biology is an integrated solution featuring a refurbished ArrayScan HCS Reader. The platform is equipped with a suite of Thermo Scientific Cellomics BioApplications software algorithms for comprehensive multiparametric assay capability. Rich cellular data is managed automatically by a complete range of HCS informatics tools.

Automated Tools for Systems Biology

The power of the Thermo Scientific Cellomics Specialized BioApplications

The automated analysis of neuronal maturation and pathology by the Extended Neurite Outgrowth BioApplication includes quantification of somal morphology along with neurite length and neurite branching measurements. The image (left) displays the masking of individual neurons by the algorithm with branch points depicted with yellow boxes. The cells were immunofluorescently labeled with an antibody to Tubulin.

The automated analysis of tumor cell motility by the Cell Motility BioApplication includes the quantification of motility track size and quantity. The image (left) displays the masking of individual motility tracks that have been produced on a lawn of fluorescent spheres by cancer cells migrating over an extracellular matrix protein.

The power of the Thermo Scientific Cellomics Core BioApplications

The Core BioApplications include automated analysis of a wide range of biological events. The Core BioApplications are general image analysis tools for multiplexed HCS assays. Compartmental Analysis features comprehensive cell segmentation for quantification of molecular movement and colocalization. Target Activation features tools for GFP and population analysis while Morphology Explorer features sophisticated analytical capabilities for multi-cellular and sub-cellular morphometry. A selection of assays that can be analyzed using each BioApplication are highlighted below:

Target Activation
• Mitotic Indexing
• GFP Expression
• Population Analysis
• Cell Death
• Receptor Internalization

Compartmental Analysis
• Protein Trafficking
• Receptor Activation
• Signal Transduction
• Protein Co-localization
• Nuclear Receptor Analysis

Morphology Explorer
• Neurite Outgrowth
• Cell Spreading
• Cell Colony Analysis
• Cytoskeletal Analysis
• Phenotyping

Certified ArrayScan HCS Reader Specifications

Refurbished ArrayScan HCS Reader
• High Resolution CCD Camera
• Standard 5X, 10X, 10X High NA, 20X Objectives
• Standard 6-Color Capability
• High Efficiency Mercury-Xenon Illumination
• Laser Barcode Reader
• Carl Zeiss AxioVert optical Bench
• Full 1 year warranty
• 1 seat-HCS 101 Training Course - (Must be used within one year from installation)

Perpetual licenses to the following BioApplications Software:
• Extended Neurite Outgrowth BioApplication
• Cell Motility BioApplication
• Morphology Explorer BioApplication
• Target Activation BioApplication
• Compartmental Analysis BioApplication