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 Title | Authors | PDF | | Detection of Cellular Stress Responses to Drugs: Heat Shock Proteins are Powerful Cell Stress Indicators in Cell-Based, High-Content Assays | Suk J. Hong and Richik N. Ghosh | | | Quantitative Analysis of Drug Effects on Cytoskeletal Structure, Cell Morphology and the Cell Cycle by High-Content Assays | Suk J. Hong and Richik N. Ghosh | | | Assessment of Oxidative Stress and DNA Damage in Individual Cells Using Automated, Quantitative Cell-Based Imaging | Kay Opperman, Bhaskar S. Mandavilli, and Richik N. Ghosh | | | Combining Multiplexed, High-Content Analysis with Antibody Arrays to Monitor and Correlate Intracellular and Extracellular Inflammatory Responses | Kay Opperman, Eric Hommema, Brian Webb, and Richik N. Ghosh | | | High-Content Analysis of Multiple Key Proteins in the AKT Signaling Pathway | Kay Opperman, Krishna Vattem, and Richik N. Ghosh | | | Utilizing secondary high content readouts in cell-based assays as a tool to evaluate compound toxicity early in the drug discovery process | Jacob Fog, Ulla Henriksen, Betina K. Lundholt, Morten Præstegaard, Frosty Loechel | | | Toxicity profiling and cellular effects of test compounds in a broad panel of HCA assays | Frosty Loechel, Jacob Fog, Ulla Henriksen, Betina K. Lundholt, Morten Præstegaard | | | Quantitative, Cell-Based, High-Content Screening Assays for DNA Damage-Induced Cell Cycle Checkpoints | Bhaskar S. Mandavilli, Suk J. Hong, Krishna M. Vattem, and Richik N. Ghosh | | | Automated, Quantitative, Multi-Parametric Monitoring of Different Programmed Cell Death Pathways Using Cell-Based High-Content Screening Assays | Bhaskar S. Mandavilli, Krishna Vattem, and Richik N. Ghosh | | | Analysis of Danio rerio Embryos Utilizing High Content Analysis Methodology | Rebecca J. Henderson, Gang Lin, Debby Nickischer, Tim Baranowski, and Jeffrey Haskins | | | Leveraging Cellomics iQ for Rapid Assay Development in Neuronal Function and Colocalization Biologies | Debby Nickischer, Scott Keefer, Donna Miller, Brent Samson, Jeffrey R. Haskins | |
Title | Authors | PDF
| | A High Content Transmitted Light Method to Quantify β-galactosidase Activity in Senescent Cells and Multi-mode Imaging Strategy to Quantitate in Cell Culture | Marni B. Tierno, Salony Maniar, Debby Nickischer, Paul Johnston, and Scott Keefer |  | | An HCS Comparison of a Compound Library’s Effects on Synaptic Function in Primary Rat Cortical Cultures | Rebecca J. Henderson, Debby Nickischer, and Scott R. Keefer | | | A High Content Screening Approach for Measuring Neuronal Function | Amy M. Peters, Donna M. Miller, Gang Lin, and Jeffrey R. Haskins | | Colocalization Studies on Cytochrome-c with Mitochondria
| Brent Samson, Oleg Lapets, Jeffery Haskins and Chandrasekaran Vasudevan | | Effective Cell Identification and Segmentation in Fluorescence Microscopy with New Flourescent Whole Cell Stains
| Suk J. Hong, Richik N. Ghosh
| | | Tolerance to Oxygen Glucose Deprivation in Differentiated Adult Hippocampal Neuronal Stem Cells Obtained from Arctic Ground Squirrels (Spermophilus parryii) | K.L. Drew, M.S. Wells, S.L. Christian, and J.A. Kelleher-Andersson. | | | A New Way to Study the PI3-Kinase Signaling Pathway Using the AKT Isoforms 1, 2 and 3. | Kay Opperman, in Pierce Previews 11(3):16-18. | | | New Fluorescent Whole Cell Stains for Effective Cell Identification and Segmentation in Fluorescence Microscopy and High Content Screening Assays | Suk J. Hong, Richik N. Ghosh | | | Novel, Multiplexed, High Content Screening Cell-Based Assays for Activation of the Transcription Factors HIF-1a, CREB, & FOXO3a | Kay Opperman, Janaki Narahari, and Richik N. Ghosh | | | Evaluation of p53 Induction Using High Content Screening | Ann F. Hoffman, Shannon M. Hamilton, Krishna M. Vatten, Janaki Narahari, and Richik N. Ghosh | | | New High Content Screening and Cell-Based Assays for Inflammation | Kay Opperman, and Richik N. Ghosh | | | A New Panel of High Content Screening Cell-Based Assays for in vitro Cytotoxicity Measurements | Bhaskar Mandavilli, Megan Cuda, Chandrasekaran Vasudevan, Richik N. Ghosh | | | Simultaneous, Quantitative Monitoring of Cytoskeleton Rearrangement and Morphology Changes in Cells Using High Content Analysis | Suk J. Hong, Richik N. Ghosh | | | A Novel High Content Screening Assay for Monitoring Cell Proliferation Activity by Multiplexed Measurements of DNA Content, BrdU and Ki67 | Suk J. Hong, Richik N. Ghosh | | | Profiling of Multiple Signal Pathway Activities by Multiplexing Antibody and GFP-based Translocation Assays | Ulla Henriksen, Kay Opperman, Jacob Fog, Richik N. Ghosh, Frosty Loechel, Morten Praestegaard | | | New High Content Screening Reagent Kits to Monitor Induction of p53 and its Downstream Targets | Krishna M. Vattem, Janaki Narahari, Richik N. Ghosh | | | New High Content Screening Reagent Kits Enabling Simultaneous Quantitative Monitoring of Cytoskeleton Rearrangement and Cell Morphology Changes | Suk J. Hong, Michael Anhalt, and Richik N.Ghosh | | | New Reagent Kits for the High Content Analysis of Cell Proliferation Activity using BrdU Incorporation and Ki67 Expression | Suk J. Hong, Kay Opperman, Richik N. Ghosh | | | New Transcription Factor Activation Kits for High Content Screening and Cell Based Assays | Kay Opperman, Roberta Litavecz, Janaki Narahari, and Richik N. Ghosh | | | New Dylight™ Fluorescence Dyes for High Content Screening and Fluorescence Cell-Based Assays | Richik N. Ghosh, Krishna M. Vattem, Zakir Murtaza, Mike Stanaitis, Chandrasekaran Vasudevan, Boguslawa R. Dworecki, Pauli Undesser, Surbhi Desai, Matthias Wenzel | | | Novel High Content Screening Assays for Measuring the Wnt and TGF-beta Signaling Pathways | Roberta Litavecz, Kay Opperman, Richik N. Ghosh | | | Multiplexing of Antibody and GFP-based Translocation Assays: A Pathway to Better Profiling of Cellular Signalling | Ulla Henriksen, Kay Opperman, Jacob Fog, Richik N. Ghosh, Frosty Loechel, Morten Praestegaard | | | New Reagent Kits for High Content Cell-Based Assays for Cytotoxicity | Jeffrey R. Haskins, Bhaskar Mandavilli, Megan Cuda, Chandrasekaran Vasudevan, and Richik N. Ghosh | | | Kinetic Viability Study of Living Cells Using an Automated High Content Platform | Rebecca J. Henderson, Debby Nickischer, and Scott R. Keefer | |
Title | Authors | PDF | | Characterization of Compound Effects on Neuronal Morphology and Neurite Outgrowth Using Automated Image Analysis System | Amy M. Peters, Everett Ramer, Oleg Lapets, Lisa Reuter, Sarah B. Tencza, and Jeffrey Haskins | | | Evaluation of the Cytokinesis-Block Method for Assessing Genotoxixity | Amy M. Peters, Megan Cuda, Lisa Reuter, and Jeffrey Haskins | | | Neuronal Morphology and Neurite Outgrowth Characterization Using An Automated Image Analysis System | Amy M. Peters, Everett Ramer, Oleg Lapets, Lisa Reuter, Sarah Tencza, and Jeffrey Haskins | | | Comparison of Manual Flask-Based vs. Cellomics Microplate-based Cytotoxicity Assay Methods | Chris Larson, Abe Dalu, Herve Lebrec, Jon Ingelfield, Sarah Tencza | | | High Content Screening for Apoptosis in Drug Discovery | B. Nickel, C. Paroz, C. Falk, P Zbinden, U. Regenass, C. Bunker | | | Performance of New DyLight Fluorescence Dyes in High Content Assays | Richik N. Ghosh , Krishna M. Vattem, Zakir Murtaza, Mike Stanaitis, Chandrasekaran Vasudevan, Boguslawa R. Dworecki, Pauli Undesser, Surbhi Desai, Mattias Wenzel | | | High Content Analysis of Induction of p53 and its Downstream Targets | Krishna M. Vattem, Janaki Narahari, Richik N. Ghosh | | | Assessing Toxicity of Nanoparticles with In Vitro Cell Based Assays | Chandrasekaran Vasudevan, Jeffrey A. Haskins, William E. Burmeister, Tom Komorowski, and Lori Bestervelt | | | Extending High Content Analysis to Models of Animal Injury | Megan Cuda, Jason Callio, Charleen Chu, Lisa Reuter, Everett Ramer and Jeffrey R. Haskins | | | A Quantitative, Automated, High Content Screening Assay for Angiogenic Tube Formation | Linnette E. Grove, Oleg Lapets, and Richik N. Ghosh | | | Leveraging the Power of High Content Screening for Monitoring Oxidative Stress | Chandrasekaran Vasudevan, and Jeffrey A. Haskins | | | Modulation of Bile Efflux in Rat Hepatocytes: A Novel Method for Quantitation of Transporter Inhibition | Jane Hopwood, C. Summers, G. Barrett, K. Jones, F. Pognan and G. Kenna | |
Title | Authors | PDF | | Cell Type Specificity for ATF-2 Activation | Amy M. Peters and Jeffrey R. Haskins | | | Optimizing Knowledge Extraction from Multiparametric, High-content Experimental Results | Megan E. Cuda, Amy M. Peters and Jeffrey R. Haskins | | | An Informatics Architecture for High Content Analysis | Mark A. Collins, Wallace Czekalski, R.Terry Dunlay | | | Value of Incorporation of an Oxidative Stress Biomarker into High Content Screening (HCS) for Human Toxicity Potential | Gareth W. Phillips, William A. Irwin, Elodie J. Howard-Cofield, Laura E. Randle, Vivek C. Abraham, Jeffrey R. Haskins and Peter J. O'Brien | | | Identification of Kinases Affecting Downstream Phenotypic Changes in Cell Morphology and Cytoskeleton by the High Content Screening Evaluation of a siRNA Library | Richik N. Ghosh, Michael A. Sipe, Linnette E. Grove, Rich Jarvis, Mike Byrom, David Brown & Jeffrey R. Haskins | | | Measurement of Oxidative Stress using Kinetic High Content Cell-based Assays | Vivek C. Abraham and Jeffrey R. Haskins | | | The Cellomics HCi Appliance | Balaji Veeraraghavan | |
Title | Authors | PDF | | A High Content Screening Assay For The Automated Quantitative Analysis Of Colony Formation and Morphology | Linnette Grove, Richik N. Ghosh, Oleg Lapets and Everett Ramer | | | Application of High Content Screening to the Analysis of Stem Cell Growth & Differentiation | V. C. Abraham, R. N. Ghosh, P. Sammak, P. Petrosko and J. R. Haskins | | | Automated Correlative Analysis of Multiparametric Cellular Responses Measured using High Content Screening | Vivek C. Abraham, Brent Samson, Oleg Lapets and Jeffrey R. Haskins | | | Automated Dual Antibody High-Content Screening on the BioCube* System | Jason Quarles, Erica Webber, Megan Cuda, Jeff Haskins, Greg Endress | | | Automated Quantitative Analysis of Cytoskeletal Rearrangement Over Multiple Spatial Dimensions Using High Content Screening | Linnette Grove, Richik N. Ghosh, Oleg Lapets and Everett Ramer | | | High Content Screening for Vasopressin Receptor Agonists Using GFP-Beta-Arrestin | Richard DeBiasio, Christine C. Hudson, Everett R. Ramer, Robert H. Oakley and Richik N. Ghosh | | | High-Content Profiling of Cell Cycle Related Targets with RNAi | Sarah Burroughs Tencza and Jeffrey R. Haskins | | | In Vitro Analysis of Multiparametric Cytotoxicity at the Individual Cell Level | Vivek C. Abraham, Brent Samson, Oleg Lapets and Jeffrey R. Haskins | | | Optical Sectioning With the Apotome Attachment on the ArrayScan HCS Reader Enhances High Content Screening Assays | Richard DeBiasio, Richik N. Ghosh, Alexander L. Friedman and Jeffrey R. Haskins | | | Optimizing Knowledge Extraction from Multiparametric, High-content Experimental Results | Megan E. Cuda, Amy M. Peters and Jeffrey R. Haskins | | | Overcoming the Expert Bottleneck: Automated Validation of High Throughput Experiments using the Medical Literature | Mark A. Collins | | | P-glycoprotein Expression Level and its Impact on Clastogenicity | Amy M. Peters and Jeffrey R. Haskins | | | Quantitative Analysis of Cell Morphology Over Multiple Dimensions Using An Automated High Content Screening Assay | Richik N. Ghosh, Oleg Lapets, Linnette Grove and Everett Ramer | | | Quantitative High Content Screening Evaluation of a siRNA Kinase Library on Downstream Phenotypic Changes in Cell Morphology and Cytoskeletal Rearrangement | Richik N. Ghosh, Linnette Grove, David Dorris, Rich Jarvis, David Brown and Jeffrey R. Haskins | | | The Use of Cryopreserved Primary Neurons in High Content Screening Assays | Richard DeBiasio and Richik N. Ghosh | | | The Use of Division-Arrested Cells Improves the Robustness of High Content Screening Assays | Chandrasekaran Vasudevan, Patrick Maunder, Jeffrey Haskins, Natalie Fursov Mei Cong and Zhong Zhong | | | Use Of An Automated High Content Screening Assay To Quantify Myotube Formation And Morphology | Linnette Grove, Richik N. Ghosh, Oleg Lapets and Everett Ramer | | | Use of Kinetic High Content Cell-based Assays for Rapid Profiling of Compound Toxicity | Brent Samson, Vivek C. Abraham, Oleg Lapets and Jeffrey R. Haskins | |
Title | Authors | PDF | | A Kinetic High Content Screening Assay for Intracellular Compartmental Analysis in Single Cells | Richik N. Ghosh, Vivek Abraham, Linnette Grove, Oleg Lapets and Jeffrey R. Haskins | | | A Quantitative Cell-Based High Content Screening Assay for Cell Cycle | Richik N. Ghosh, Linnette Grove and Oleg Lapets | | | Automated Analysis for Micronucleus Induction Using A Cell-Based High Content Screening Application | Amy Drzal, Jeff Peterson, Jessika Strauss, Megan Weiss and Jeffrey R. Haskins | | | Automated Cell-Based Quantitation of Neurite Outgrowth and Neuronal Cell Differentiation Using Cellomics? Neurite Outgrowth BioApplications | Everett Ramer, Stuart Arden, Richik Ghosh and Jeffrey R. Haskins | | | Automated Kinetic Analysis of Simultaneous Events in Single Cells Can Expose Details of Cytotoxic Mechanisms | Vivek Abraham, Megan Weiss, Oleg Lapets and Jeffrey R. Haskins | | | Decoupling Retinoblastoma Protein Dephosphorylation From Mitosis | Richik N. Ghosh and Linnette Grove | | | High-Content Screening of Gene Knock-downs Induced with siRNA Transfection | Yih-Tai Chen, Kenneth A. Guiliano, and Jeffrey R. Haskins | | | Large-Scale Investigation of Cytotoxicity Enabled by Automated Simultaneous Monitoring of Multiple Intracellular Processes in Individual Living Cells | Vivek C. Abraham, Brent Samson, Oleg Lapets and Jeffrey R. Haskins | | | Positional Biosensors Enable Large-Scale Investigation of Apoptotic Mechanisms of Cell Death | Jeffrey R. Haskins, Chandrasekaran Vasudevan, Patrick Maunder and Yih-Tai Chen | | | Positional Biosensors: A New Tool for High-Content Screening | Kenneth A. Giuliano, Yih-Tai Chen and Jeffrey R. Haskins | | | Quantitation of Cytoplasm to Cell Membrane Translocation of Proteins Using a Specially Designed High Content Screening BioApplication | Vivek Abraham, Jessika Strauss, Brent Samson, Jeffrey Peterson and Jeffrey R. Haskins | | | Ranking of Beta2 Adrenergic Receptor Agonists and Antagonists Using a Cell-Based GPCR Signaling Application | Chandrasekaran Vasudevan and Jeffrey R. Haskins | | | Relationship of P-glycoprotein and clastogenicity in vitro | Amy M. Peters, Megan E. Weiss, and Jeffrey R. Haskins | | | Simultaneous and Quantitative Analysis of Signal Transduction Pathways with a Cell-Based High Content Screening Application | Chandrasekaran Vasudevan, Oleg Lapets and Jeffrey R. Haskins | | | Unlocking the Power of Optical Sectioning with the ArrayScan V HCS Reader | Cellomics, Inc. | | | Use of Cellomics High Content Screening Platform to Increase Efficiency and Output for Small Molecule and Therapeutic Protein Discovery | Anthony Nichols, Francois Duval, Astrid Osen-Sand, Lilia Bernasconi-Castelli, Elisabeth Allet, Sandrine Pouly, Yves Sagot, Paul Lang and Alexander Scheer | | | Validation of siRNA Gene Knockdown Through Automated Phenotypic Analysis of Cellular Function | Yih-Tai Chen, Kenneth A. Giuliano, and Jeffrey R. Haskins | |
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